Investigation and replication of these findings are required to improve our understanding of theĮffects of intranasal oxytocin on autonomic functioning both at rest and under cognitive stress. Intranasal oxytocin may enhance the salience of the mental arithmetic task, leading to reducedĮngagement of the parasympathetic nervous system when completing the task. However, compared to placebo, intranasal oxytocin elicited small decreases in low-frequencyĪnd high-frequency HRV in both groups during the mental arithmetic task. Intranasal oxytocin did not influence HRV at Recorded at rest and during a mental arithmetic task. In a randomised double-blind, placebo-controlled, cross-over study, participants self-Īdministered intranasal oxytocin (24 IU) in one session, and placebo in another, before HRV was With chronic neck and shoulder pain lasting > 12 months and 24 age- and sex-matched pain-freeĬontrols. Oxytocin on HRV in persons with chronic neck and shoulder pain. This study investigated the impact of intranasal On HRV in persons with chronic pain is unknown. Hormone oxytocin has been shown to increase HRV in non-clinical samples, but its potential impact Often display autonomic dysregulation, especially in the parasympathetic nervous system. HRV is an indicator of potential autonomic nervous system dysfunction. Heart rate variability (HRV) refers to variation in the interval between successive heart beats. School of Psychological Sciences and Monash Institute for Cognitive and Clinical Neurosciences Institute for Safety, Compensation & Recovery Research, Melbourne, VIC, Australia School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia School of Psychology, Australian Catholic University, Fitzroy, VIC, Australia National Ageing Research Institute, Parkville, VIC, Australia Monash University, Clayton, VIC, AustraliaĬaulfield Pain Management & Research Centre, Caulfield Hospital, Caulfield, VIC, Australia School of Psychological Sciences and Monash Institute for Cognitive and Clinical Neurosciences, Gibson b,c, Izelle Labuschagned, Nellie Georgiou-Karistianisa, Melita J. Intranasal oxytocin reduces heart rate variability during a mental arithmetic task: A randomised,ĭouble-blind, placebo-controlled cross-over study Please note that during the production process errors mayīe discovered which could affect the content, and all legal disclaimers that apply to the Manuscript will undergo copyediting, typesetting, and review of the resulting proof before AsĪ service to our customers we are providing this early version of the manuscript.
This is a PDF file of an unedited manuscript that has been accepted for publication. The address for the corresponding author was captured asĪffiliation for all authors. Rate variability during a mental arithmetic task: A randomised, double-blind, placebocontrolled cross-over study. Giummarra, Intranasal oxytocin reduces heart Progress in Neuropsychopharmacology & Biological Psychiatry
Intranasal oxytocin reduces heart rate variability during a mentalĪrithmetic task: A randomised, double-blind, placebo-controlled